Ray Lewis - Madden 2005. They introduced the Hit stick during this Madden. With Ray Lewis in the prime of his career, he was unbelievable in this game. Seriously, you couldn't run towards Ray Lewis at all in this game without fumbling the ball. Lewis in zone was unstoppable too, the middle of field was essentially locked down the entire game because of him.
Michael Vick - Madden 2004. You either had a lot of great memories playing with Vick or you build up anger every time you hear his name because he rushed 150 yards in a game against you and threw for 300 yards. It was impossible not to move the chains with Michael Vick. You didn't even need to utilize your running backs at all, just use Vick to scramble

Patrick Willis - Madden 13. Pretty much the same thing I said about Lewis applies to Willis. He was unstoppable with whatever he did. If you sent him on a blitz, he'd get past protection with ease. He stops the run and of course his hitting power guarantees a fumble when you properly size him up.